NYS HIV PrEP Guidelines

Clinicians should discuss PrEP with the following non-HIV-infected individuals who have substantial and ongoing risk:


  • Men who have sex with men (MSM) who engage in unprotected anal intercourse7,8
  • Individuals who are in a serodiscordant sexual relationship with a known HIV-infected partner
  • Male-to-female and female-to male transgender individuals engaging in high-risk sexual behaviors
  • Individuals engaging in transactional sex, such as sex for money, drugs, or housing
  • Injection drug users who report any of the following behaviors: sharing injection equipment (including to inject hormones among transgender individuals), injecting one or more times per day, injecting cocaine or methamphetamine, engaging in high-risk sexual behaviors6
  • Individuals who use stimulant drugs associated with high-risk behaviors, such as methamphetamine7-11
  • Individuals diagnosed with more than one anogenital sexually transmitted infection in the last year9
  • Individuals who have been prescribed non-occupational post-exposure prophylaxis (nPEP) who demonstrate continued high-risk behavior or have used multiple courses of nPEP12